[HTML][HTML] Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis
C Garcés, MJ Ruiz-Hidalgo, JF de Mora, C Park… - Journal of Biological …, 1997 - ASBMB
Notch, a transmembrane receptor member of the homeotic epidermal growth factor-like
family of proteins, participates in cell-to-cell signaling to control cell fate during development.
Activated Notch-1 constructs lacking the extracellular region prevent differentiation of
several mammalian cells in vitro. This effect, however, bypasses the normal mechanisms of
cell-to-cell interactions in which Notch-1 participates. We investigated the role of Notch-1 in
the hormone-induced adipocyte differentiation of 3T3-L1 fibroblasts, a paradigmatic model …
family of proteins, participates in cell-to-cell signaling to control cell fate during development.
Activated Notch-1 constructs lacking the extracellular region prevent differentiation of
several mammalian cells in vitro. This effect, however, bypasses the normal mechanisms of
cell-to-cell interactions in which Notch-1 participates. We investigated the role of Notch-1 in
the hormone-induced adipocyte differentiation of 3T3-L1 fibroblasts, a paradigmatic model …