The influence of genetic background on the expression of the obese (Ob) gene in the mouse.

Coleman DL; Hummel KP

doi:10.1007/bf01221856

The influence of genetic background on the expression of the obese (Ob) gene in the mouse.

Diabetologia, 01 Aug 1973, 9(4):287-293
https://doi.org/10.1007/bf01221856 PMID: 4588246

A comment on this article appears in "Deconstructing obesity: the face of fatness before and after the discovery of leptin." Diabetologia. 2012 Jan;55(1):3-6.

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References

Articles referenced by this article (14)

Bleisch, V.R., Mayer, J., Dickie, M.M.: Familial diabetes mellitus in mice associated with insulin resistance, obesity, and hyperplasia of the islets of Langerhans. Amer. J. Path.28, 369-385 (1952).
Studies with the mutation, diabetes, in the mouse.
Coleman DL, Hummel KP
Diabetologia, (2):238-248 1967
MED: 4907142
Insulin resistance in genetically obese, hyperglycemic mice.
Genuth SM, Przybylski RJ, Rosenberg DM
Endocrinology, (5):1230-1238 1971
MED: 5278387
Methodological approaches to studies on the pancreatic islets.
Hellman B
Diabetologia, (2):110-120 1970
MED: 4192895
Differences in the development of the obese-hyperglycemic syndrome in obob and NZO mice.
Herberg L, Major E, Hennigs U, Gruneklee D, Freytag G, Gries FA
Diabetologia, (3):292-299 1970
MED: 4914666
The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL-KsJ and C57BL-6J strains.
Hummel KP, Coleman DL, Lane PW
Biochem Genet, (1):1-13 1972
MED: 4557514
Obese, a new mutation in the house mouse.
INGALLS AM, DICKIE MM, SNELL GD
J Hered, (12):317-318 1950
MED: 14824537
Effect of a high-fat diet on obese-hyperglycaemic and non-obese Bar Harbor mice.
Lemonnier D, Winand J, Furnelle J, Christophe J
Diabetologia, (5):328-333 1971
MED: 5134254
Lever, J.D., Findlay, J.A.: Histological observations on the pancreas of the genetically obese mouse (Birmingham strain) with particular reference to the islets of Langerhans. J. Anat.108, 620 Abst. (1971).
A quantitative method of determination of the diabetogenic activity of growth hormone preparations.
MAYER J, SILIDES DN
Endocrinology, (1):54-56 1953
MED: 13021111

Show 4 more references (10 of 14)

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Proteins in UniProt (Showing 5 of 11)

Leptin receptor(UniProt - A2AV66)
Leptin(UniProt - Q544U0)
Leptin receptor(UniProt - D0FZQ3)
Leptin(UniProt - E9M0G2)
Leptin(UniProt - P41160)

Go to all (11) records in UniProt

Mouse Genome Informatics (MGI)

http://www.informatics.jax.org/reference/4588246

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The influence of genetic background on the expression of the obese (Ob) gene in the mouse.

Abstract

Full text links

References

Bleisch, V.R., Mayer, J., Dickie, M.M.: Familial diabetes mellitus in mice associated with insulin resistance, obesity, and hyperplasia of the islets of Langerhans. Amer. J. Path.28, 369-385 (1952).

Studies with the mutation, diabetes, in the mouse.

Insulin resistance in genetically obese, hyperglycemic mice.

Methodological approaches to studies on the pancreatic islets.

Differences in the development of the obese-hyperglycemic syndrome in obob and NZO mice.

The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL-KsJ and C57BL-6J strains.

Obese, a new mutation in the house mouse.

Effect of a high-fat diet on obese-hyperglycaemic and non-obese Bar Harbor mice.

Lever, J.D., Findlay, J.A.: Histological observations on the pancreas of the genetically obese mouse (Birmingham strain) with particular reference to the islets of Langerhans. J. Anat.108, 620 Abst. (1971).

A quantitative method of determination of the diabetogenic activity of growth hormone preparations.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Leptin signalling regulates transcriptional differences in granulosa cells from genetically obese mice but not the activation of NLRP3 inflammasome.

Assessment of Inner Blood-Retinal Barrier: Animal Models and Methods.

Sex- and age-dependent contribution of System x_c^- to cognitive, sensory, and social behaviors revealed by comprehensive behavioral analyses of System x_c^- null mice.

What the BTBR/J mouse has taught us about diabetes and diabetic complications.

Mammalian models of diabetes mellitus, with a focus on type 2 diabetes mellitus.

Data

Data that cites the article

Proteins in UniProt (Showing 5 of 11)

Mouse Genome Informatics (MGI)

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