Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Different metabolic responses of human brown adipose tissue to activation by cold and insulin.

Author information

Affiliations

  • 1. Turku PET Centre, University of Turku, Turku, Finland.
      Authors
    • Orava J 1
    (1 author)

ORCIDs linked to this article

Cell Metabolism, 01 Aug 2011, 14(2):272-279
https://doi.org/10.1016/j.cmet.2011.06.012 PMID: 21803297 

Abstract 

We investigated the metabolism of human brown adipose tissue (BAT) in healthy subjects by determining its cold-induced and insulin-stimulated glucose uptake and blood flow (perfusion) using positron emission tomography (PET) combined with computed tomography (CT). Second, we assessed gene expression in human BAT and white adipose tissue (WAT). Glucose uptake was induced 12-fold in BAT by cold, accompanied by doubling of perfusion. We found a positive association between whole-body energy expenditure and BAT perfusion. Insulin enhanced glucose uptake 5-fold in BAT independently of its perfusion, while the effect on WAT was weaker. The gene expression level of insulin-sensitive glucose transporter GLUT4 was also higher in BAT as compared to WAT. In conclusion, BAT appears to be differently activated by insulin and cold; in response to insulin, BAT displays high glucose uptake without increased perfusion, but when activated by cold, it dissipates energy in a perfusion-dependent manner.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.cmet.2011.06.012

Read article for free, from open access legal sources, via Unpaywall: http://www.cell.com/article/S1550413111002610/pdfUnpaywall

References 

Articles referenced by this article (26)

Show 10 more references (10 of 26)

Citations & impact 

Impact metrics

421
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/101874887
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/101874887

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/j.cmet.2011.06.012

Supporting
Mentioning
Contrasting
46
538
6

Article citations

Go to all (421) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.