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Notch signalling: a simple pathway becomes complex.

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Affiliations

  • 1. Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.
      Authors
    • Bray SJ 1
    (1 author)

ORCIDs linked to this article

Nature reviews. Molecular Cell Biology, 01 Sep 2006, 7(9):678-689
https://doi.org/10.1038/nrm2009 PMID: 16921404 

Review

Abstract 

A small number of signalling pathways are used iteratively to regulate cell fates, cell proliferation and cell death in development. Notch is the receptor in one such pathway, and is unusual in that most of its ligands are also transmembrane proteins; therefore signalling is restricted to neighbouring cells. Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.

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Funding 

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Medical Research Council (1)

Wellcome Trust